Structure of Enterohemorrhagic Escherichia coli O157:H7 Intimin Virulence Factor Bound to Nanobodies
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چکیده
منابع مشابه
Enterohemorrhagic Escherichia coli Virulence Gene Regulation.
Coordinated expression of enterohemorrhagic Escherichia coli virulence genes enables the bacterium to cause hemorrhagic colitis and the complication known as hemolytic-uremic syndrome. Horizontally acquired genes and those common to E. coli contribute to the disease process, and increased virulence gene expression is correlated with more severe disease in humans. Researchers have gained conside...
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Enteric pathogens with low infectious doses rely on the ability to orchestrate the expression of virulence and metabolism-associated genes in response to environmental cues for successful infection. Accordingly, the human pathogen enterohemorrhagic Escherichia coli (EHEC) employs a complex multifaceted regulatory network to link the expression of type III secretion system (T3SS) components to n...
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The biogeography of the gut is diverse in its longitudinal axis, as well as within specific microenvironments. Differential oxygenation and nutrient composition drive the membership of microbial communities in these habitats. Moreover, enteric pathogens can orchestrate further modifications to gain a competitive advantage toward host colonization. These pathogens are versatile and adept when ex...
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Enteropathogenic and Enterohemorrhagic Escherichia coli Virulence Gene Regulation Jay L. Mellies,* Alex M. S. Barron, and Anna M. Carmona Biology Department, Reed College, 3203 S.E. Woodstock Boulevard, Portland, Oregon 97202; Oregon Health Sciences University, L215, 3181 S.W. Sam Jackson Park Rd., Portland, Oregon 97239; and School of Public Health, University of California, Berkeley, 140 Warr...
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Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) produce the characteristic "attaching and effacing" (A/E) lesion of the brush border. Intimin, an outer membrane protein encoded by eae, is responsible for the tight association of both pathogens with the host cell. Several eae have been cloned from different EPEC and EHEC strains isolated from humans and animals. The...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.04066